BackgroundObesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to support breast cancer progression is poorly understood.ResultsHere, we show that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of adipocyte triacylglycerol. Adipocyte-derived free fatty acids were transferred to breast cancer cells, driving fatty acid metabolism via increased CPT1A and electron transport chain complex protein levels, resulting in increased proliferation and migration. Notably, fatty acid transfer to breast cancer cells was enhanced from “obese” adipocytes, concomitant with increased stimulation of cancer cell proliferation and migration. This adipocyte-stimulated breast cancer cell proliferation was dependent on lipolytic processes since HSL/ATGL knockdown attenuated cancer cell responses.ConclusionsThese findings highlight a novel and potentially important role for adipocyte lipolysis in the provision of metabolic substrates to breast cancer cells, thereby supporting cancer progression.

中文翻译：

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脂肪细胞脂解将肥胖与乳腺癌生长联系起来：脂肪细胞衍生的脂肪酸驱动乳腺癌细胞增殖和迁移

背景肥胖与乳腺癌的复发率增加和存活率降低有关。脂肪细胞是乳腺组织的重要组成部分，但它们在提供代谢底物以支持乳腺癌进展方面的作用知之甚少。结果在这里，我们表明乳腺癌细胞与脂肪细胞的共培养揭示了癌细胞刺激的脂肪细胞三酰甘油消耗。脂肪细胞来源的游离脂肪酸被转移到乳腺癌细胞，通过增加 CPT1A 和电子传递链复合蛋白水平来驱动脂肪酸代谢，导致增殖和迁移增加。值得注意的是，脂肪酸从“肥胖”脂肪细胞转移到乳腺癌细胞的能力增强，同时对癌细胞增殖和迁移的刺激增加。