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Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease.
Redox Report ( IF 3.8 ) Pub Date : 2017-01-11 , DOI: 10.1080/13510002.2016.1276314
David M Small 1 , Kassia S Beetham 2 , Erin J Howden 2 , David R Briskey 2 , David W Johnson 1, 3 , Nicole M Isbel 1, 3 , Glenda C Gobe 1 , Jeff S Coombes 2
Affiliation  

Objectives: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients.

Methods: A total of 136 stage 3–4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months.

Results: There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (p = 0.88), GPX (p = 0.87), or TAC (p = 0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (p = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (p = 0.33).

Discussion: Exercise and lifestyle modification in stage 3–4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.



中文翻译:

运动和生活方式干预对慢性肾脏疾病氧化应激的影响。

目的:确定一项为期12个月的运动和生活方式干预计划对透析前慢性肾脏病(CKD)患者血浆氧化应激生物标志物变化的影响。

方法:总共136名3–4期CKD患者被随机分配接受标准的肾脏病护理,有(N  = 72)或没有(N  = 64)生活方式和运动干预,为期12个月。在基线和12个月时收集血浆总F 2-异前列腺素(IsoP),谷胱甘肽过氧化物酶(GPX)活性,总抗氧化剂能力(TAC),人体测量学和生化数据。

结果:基线时各组之间无显着差异。在标准护理和生活方式干预方面,IsoP(p  = 0.88),GPX(p  = 0.87)或TAC(p  = 0.56)的变化无显着差异。与标准护理相比,在生活方式干预下被确定为基线时具有较高IsoP(> 250 pg / mL)的患者,其IsoP降低更大。但是,差异无统计学意义(p  = 0.06)。标准护理和生活方式干预之间的肾功能(eGFR)变化无差异(p  = 0.33)。

讨论:在3-4个CKD阶段的锻炼和生活方式改变在12个月内并未产生氧化应激的全身性生物标志物变化,但IsoP较高的患者可能会从标准护理中增加干预措施而受益最大。

更新日期:2017-01-11
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