Lipophilic persistent organic pollutants (POP) are stored in adipose tissue. Following rapid weight loss such as when induced by bariatric surgery, an increased release of potential harmful lipophilic compounds into the blood circulation may occur. Weight reduction is recommended for overweight and obese individuals in order to decrease risk of weight-related health problems. However, in cases of significant weight reduction POP become mobilized chemicals and consequently may adversely affect health, including endocrine disruption. The objective of the present investigation was to estimate quantitatively the level of mobilization of POP following weight loss over time. According to literature search criteria, 17 studies were identified with 2061 participants. Data from 5 of the studies with 270 participants were used to assess the change in blood levels of POP in percent per kilogram weight loss. Weight loss in the included studies varied from 4.4 to 64.8 kg. In all studies, the majority of POP concentrations in blood were found to rise following weight reduction. Blood concentrations following weight reduction were elevated by 2-4% per kilogram weight loss for most POP examined. The increased POP levels were still elevated 12 mo after intervention. Most research in this field, including animal studies, is carried out on a single compound or group of selected compounds, not taking the "cocktail effect" into consideration. This does not reflect the true range of POP to which humans are actually exposed. Few chronic investigations have been published and, in particular, few studies were available that compared the increase in POP concentrations with clinical consequences as individuals lost weight. These limitations call for caution in interpreting results. The benefits of losing weight still far outweigh the potential adverse health risks. However, further studies are recommended to determine the clinical significance of increased blood levels of POPs following rapid and excessive weight loss, particularly for women attending weight reduction treatment before pregnancy.

中文翻译：

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减肥后肥胖个体血液中持久性有机污染物（POP）的水平升高-一项综述。

亲脂性持久性有机污染物（POP）存储在脂肪组织中。在快速减肥之后（例如通过减肥手术引起的减肥后），潜在有害的亲脂性化合物向血液循环的释放可能会增加。建议为超重和肥胖的人减轻体重，以减少与体重有关的健康问题的风险。但是，如果体重显着减少，则POP会成为一种动员的化学物质，因此可能对健康产生不利影响，包括内分泌干扰。本研究的目的是定量估计随着时间的流逝体重减轻后POP的动员水平。根据文献检索标准，确定了17项研究，共有2061名参与者。来自270名参与者的5项研究的数据用于评估POP血液中每公斤体重减轻百分比的变化。纳入研究的体重减轻范围为4.4至64.8 kg。在所有研究中，发现体重减轻后血液中大部分POP浓度会升高。对于大多数所检查的POP，体重减轻后的血液浓度每公斤体重减轻增加2-4％。干预后12个月，POP水平升高。在该领域中的大多数研究，包括动物研究，都是在单个化合物或一组选定的化合物上进行的，没有考虑“鸡尾酒效应”。这不能反映出人类实际接触到的POP的真实范围。很少发表长期研究报告，尤其是 很少有研究将POP浓度的增加与个体减肥引起的临床后果进行比较。这些限制要求在解释结果时要谨慎。减肥的好处仍然远远超过潜在的不利健康风险。但是，建议进行进一步的研究以确定快速和过度减肥后POPs血药浓度升高的临床意义，尤其是对于怀孕前接受减重治疗的女性。