Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.

中文翻译：

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REV-ERBα基因敲除小鼠的机械伤害感受性轻度增加。

伤害感受是最复杂的感觉之一，不仅受外部刺激，而且受内部条件影响。先前的研究表明，昼夜节律在调节伤害感受中很重要。REV-ERBα基因敲除（KO）小鼠破坏了昼夜节律并改变了与情绪有关的表型。在这项研究中，我们检查了REV-ERBα在炎性伤害感受中的作用。我们发现KO小鼠的伤害感受敏感性在机械伤害感受中得到了部分增强。但是，这种部分改变与昼夜节律无关。综上所述，REV-ERBα的缺失引起机械伤害感受敏感性的轻度变化，但这种变化与昼夜节律无关。