Objective: To examine the effect of galangin on hyperglycemia-mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.

Methods: Diabetes was induced by intraperitoneal administration of low-dose STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 µg/kg BW) was given orally, once daily for 45 days to normal and STZ-induced diabetic rats.

Results: Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes. The levels of insulin and non-enzymatic antioxidants (vitamin C, vitamin E, reduced glutathione) and the activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase (GST)) were decreased significantly in diabetic control rats. These altered plasma glucose, insulin, lipid peroxidation products, enzymatic and non-enzymatic antioxidants ions were reverted to near-normal level after the administration of galangin and glibenclamide.

Conclusion: The present study shows that galangin decreased oxidative stress and increased antioxidant status in diabetic rats, which may be due to its antidiabetic and antioxidant potential.

目的：研究高良姜精对链脲佐菌素（STZ）诱导的糖尿病大鼠高血糖介导的氧化应激的影响。

方法：通过腹腔注射低剂量STZ（40 mg / kg体重（BW））对雄性白化Wistar大鼠进行糖尿病诱导。正常和STZ诱导的糖尿病大鼠口服高良姜精（8 mg / kg BW）或格列本脲（600 µg / kg BW），每天一次，持续45天。

结果：糖尿病大鼠血浆葡萄糖，硫代巴比妥酸反应性物质，脂质氢过氧化物和共轭二烯的水平显着增加。在糖尿病控制中，胰岛素和非酶抗氧化剂（维生素C，维生素E，还原型谷胱甘肽）的水平以及酶促抗氧化剂（超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽S-转移酶（GST））的活性均显着降低。大鼠。在施用高良姜精和格列本脲后，这些改变的血浆葡萄糖，胰岛素，脂质过氧化产物，酶促和非酶促抗氧化剂离子恢复到接近正常水平。

结论：本研究表明高良姜素可降低糖尿病大鼠的氧化应激并增加其抗氧化状态，这可能是由于其具有抗糖尿病和抗氧化作用。