In this study, we have tested the effects of the dopamine D₂ receptor blocker pimozide on timing performance in patients with Tourette syndrome (TS). Nine children with TS were tested off‐medication and following 3 months of daily treatment with pimozide. Subjects completed a time reproduction and a time production task using supra‐second temporal intervals. We show that pimozide improves motor timing performance by reducing the patients' variability in reproducing the duration of visual stimuli. On the other hand, this medication has no effect on the reproduction accuracy and on both variability and accuracy of the performance on the time production task. Our results suggest that pimozide might have improved motor timing variability as a result of its beneficial side effect on endogenous dopamine levels (i.e., normalization).

中文翻译：

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与持续性匹莫齐特治疗相关的儿童Tourette综合征的时间重新校准。

在这项研究中，我们测试了多巴胺D ₂受体阻滞剂匹莫齐特对Tourette综合征（TS）患者计时性能的影响。九名TS儿童接受了药物以外的测试，并在每天3个月的使用匹莫齐治疗后进行了测试。受试者使用上述方法完成了时间复制和时间生产任务-第二个时间间隔。我们显示，匹莫齐特可通过减少患者在再现视觉刺激持续时间方面的变异性来改善运动时机性能。另一方面，这种药物对生殖准确性，时间生产任务上的性能变异性和准确性均无影响。我们的结果表明，由于匹莫齐特对内源性多巴胺水平具有有益的副作用（即归一化），因此可能改善了运动时机变异性。