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Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment.
Clinical Microbiology Reviews ( IF 36.8 ) Pub Date : 2016-12-03 , DOI: 10.1128/cmr.00010-16
Cameron Griffiths 1 , Steven J Drews 2, 3 , David J Marchant 4
Affiliation  

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria. Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection. Paradoxically, there is a very large volume of information that is constantly being refined on RSV replication, the mechanisms of RSV-induced pathology, and community transmission. Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection. A mechanistic link is even starting to emerge between asthma and those who suffer severe RSV infection early in childhood. In this article, we discuss developments in the understanding of RSV replication, pathogenesis, diagnostics, and therapeutics. We attempt to reconcile the large body of information on RSV and why after many clinical trials there is still no efficacious RSV vaccine and few therapeutics.

中文翻译:

呼吸道合胞病毒:感染,检测以及预防和治疗的新选择。

呼吸道合胞病毒(RSV)感染是北美地区儿童住院的重要原因,也是全世界1岁以下婴儿死亡的主要原因之一,仅次于疟疾。尽管它对人类健康具有全球影响,但用于预防或治疗RSV感染的治疗选择相对较少。矛盾的是,关于RSV复制,RSV引起的病理学机制和社区传播的信息不断完善。急性RSV感染的重症是先前存在的慢性气道疾病的加重和RSV感染的慢性后遗症。哮喘与儿童早期遭受严重RSV感染的人之间甚至开始出现机械联系。在本文中,我们讨论了对RSV复制,发病机理,诊断和治疗方法的了解中的发展。我们试图调和有关RSV的大量信息,以及为什么在许多临床试验后仍然没有有效的RSV疫苗和很少的疗法​​。
更新日期:2019-11-01
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