The fruitless (fru) gene in Drosophila has been proposed to play a master regulator role in the formation of neural circuitries for male courtship behavior, which is typically considered to be an innate behavior composed of a fixed action pattern as generated by the central pattern generator. However, recent studies have shed light on experience-dependent changes and sensory-input-guided plasticity in courtship behavior. For example, enhanced male-male courtship, a fru mutant “hallmark,” disappears when fru-mutant males are raised in isolation. The fact that neural fru expression is induced by neural activities in the adult invites the supposition that Fru as a chromatin regulator mediates experience-dependent epigenetic modification, which underlies the neural and behavioral plasticity.

果蝇中的无果（fru）基因被认为在男性求爱行为的神经回路的形成中起着主要的调节作用，这通常被认为是由中央模式发生器产生的由固定动作模式组成的先天行为。 。但是，最近的研究揭示了求偶行为中依赖于经验的变化和以感觉输入为指导的可塑性。例如，增强的雄性之间求爱，一个FRU突变体“标志，”时消失FRU -mutant男性中隔离被升高。神经通病的事实 成年人的神经活动诱导了这种表达，这提出了假设，即Fru作为染色质调节剂介导了经验依赖的表观遗传修饰，这是神经和行为可塑性的基础。