The normal cells derived from human embryonic stem cells (hESCs) are regarded as substitutes for damaged or dysfunctional adult cells. However, tumorigenicity of hESCs remains a major challenge in clinical application of hESC-derived cell transplantation. Previously, we generated monoclonal antibody (MAb) 57-C11 specific to the surface molecule on undifferentiated hESCs. The aim of this study is to prove whether 57-C11-positive hESCs are pluripotent and tumorigenic in immunodeficient mice.

中文翻译：

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57-C11 单克隆抗体分离的人胚胎干细胞的体内评价。

源自人类胚胎干细胞 (hESC) 的正常细胞被视为受损或功能失调的成体细胞的替代品。然而，hESCs的致瘤性仍然是hESC衍生细胞移植临床应用的主要挑战。以前，我们生成了对未分化 hESC 表面分子特异的单克隆抗体 (MAb) 57-C11。本研究的目的是证明 57-C11 阳性 hESC 在免疫缺陷小鼠中是否具有多能性和致瘤性。