This study examined the efficacy of an integrative cognitive remediation program (REHACOP) in improving cognition and functional outcome in patients with schizophrenia. The program combines cognitive remediation, social cognitive intervention, and functional skills training. Few studies have attempted this approach. One hundred and eleven patients diagnosed with schizophrenia were randomly assigned to either the cognitive remediation group (REHACOP) or an active control group (occupational activities) for 4 months (three sessions per week, 90 min). Primary outcomes were change on general neurocognitive performance and social cognition, including theory of mind (ToM), emotion perception (EP), attributional style, and social perception (SP). Secondary outcomes included changes on clinical symptoms (Positive and Negative Syndrome Scale) and functional outcome (UCSD Performance-Based Skills Assessment and the Global Assessment of Functioning). The trial was registered with clinicaltrials.gov (NCT02796417). No baseline group differences were found. Significant differences were found in the mean change between the REHACOP group and control group in neurocognition ([Formula: see text]), SP ([Formula: see text]), ToM ([Formula: see text]), EP ([Formula: see text]), negative symptoms ([Formula: see text]), emotional distress ([Formula: see text]), Global Assessment of Functioning ([Formula: see text]), and UCSD Performance-Based Skills Assessment ([Formula: see text]). The combination of cognitive remediation, social cognitive intervention, and functional skills training demonstrated statistically significant and clinically meaningful changes in neurocognition, social cognition, negative, and functional disability.

中文翻译：

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结合精神分裂症的社会认知治疗，认知矫正和功能技能培训：一项随机对照试验。

这项研究检查了综合性认知修复程序（REHACOP）在改善精神分裂症患者的认知和功能结局中的功效。该计划结合了认知补救，社会认知干预和功能技能培训。很少有研究尝试过这种方法。119名被诊断为精神分裂症的患者被随机分配到认知矫正组（REHACOP）或活动对照组（职业活动），为期4个月（每周三节，每节90分钟）。主要结果是一般神经认知表现和社交认知的变化，包括心理理论（ToM），情感认知（EP），归因方式​​和社交认知（SP）。次要结果包括临床症状（正负综合症量表）和功能结果（UCSD基于绩效的技能评估和整体功能评估）的变化。该试验已在Clinicaltrials.gov（NCT02796417）上注册。没有发现基线组差异。在REHACOP组和对照组的神经认知（[公式：参见文字]），SP（[公式：参见文字]），ToM（[公式：参见文字]），EP（[公式] ：请参见文字]），消极症状（请参见[公式：请参见文字]），情绪困扰（请参见[公式：请参见文字]），整体功能评估（请参见[公式：请参见文字]）和UCSD基于绩效的技能评估（[公式：请参见文字]）。认知补救，社会认知干预，