Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

中文翻译：

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色母细胞病。

色母细胞病（CBM），也称为色菌病，是最普遍的植入真菌感染之一，是由黑色素或棕色色素真菌引起的霉菌病最广泛的领域。煤层气主要是热带或亚热带疾病，可能会影响到全球范围内具有某些危险因素的个体。该疾病与以下特征有关：（i）通过从环境来源植入造成的创伤性接种，导致在接种部位出现最初的皮肤病变；（ii）慢性和进行性皮肤和皮下组织累及，伴有与微脓肿相关的纤维化和肉芽肿反应，通常与组织增生有关；（iii）无效的体液参与而产生的非保护性2型T辅助T2（Th2）免疫反应；（iv）包埋在患病组织中的壁状（硬化）细胞的存在。CBM病变在临床上是多态的，通常被误诊为其他各种传染性和非传染性疾病。在更严重的临床形式中，CBM可能由于纤维化后遗症以及一系列临床并发症而导致劳动能力丧失，并且如果在早期阶段未被发现，则该病可能对抗真菌治疗无效。