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Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C.
Clinical Microbiology Reviews ( IF 36.8 ) Pub Date : 2016-10-19 , DOI: 10.1128/cmr.00037-16
Eleanor M Wilson 1, 2 , Elana S Rosenthal 2 , Sarah Kattakuzhy 1, 2 , Lydia Tang 1 , Shyam Kottilil 3, 4
Affiliation  

Directly acting antiviral (DAA) combination therapies for chronic hepatitis C virus (HCV) infection are highly effective, but treatment decisions remain complex. Laboratory testing is important to evaluate a range of viral, host, and pharmacological factors when considering HCV treatment, and patients must be monitored during and after therapy for safety and to assess the viral response. In this review, we discuss the laboratory tests relevant for the treatment of HCV infection in the era of DAA therapy, grouped according to viral and host factors.

中文翻译:

丙型肝炎直接抗病毒治疗时代的临床实验室测试。

直接作用抗病毒(DAA)联合疗法治疗慢性丙型肝炎病毒(HCV)感染非常有效,但治疗决策仍然复杂。在考虑 HCV 治疗时,实验室检测对于评估一系列病毒、宿主和药理学因素非常重要,并且必须在治疗期间和治疗后对患者进行监测以确保安全性并评估病毒反应。在这篇综述中,我们讨论了 DAA 治疗时代与 HCV 感染治疗相关的实验室检测,并根据病毒和宿主因素进行分组。
更新日期:2019-11-01
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