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Vitamin D, calcium homeostasis and aging.
Bone Research ( IF 12.7 ) Pub Date : 2016-10-30 , DOI: 10.1038/boneres.2016.41
Vaishali Veldurthy 1 , Ran Wei 1 , Leyla Oz 1 , Puneet Dhawan 1 , Yong Heui Jeon 1 , Sylvia Christakos 1
Affiliation  

Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25(OH)2D3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis (which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance.

中文翻译:

维生素D,钙稳态和衰老。

骨质疏松症的特征是骨量低和骨组织的微结构恶化,导致骨脆性增强,从而导致骨折风险增加。钙缺乏的重要作用的证据正在积累,因为衰老过程与钙平衡紊乱有关。维生素D是维持钙稳态的主要因素。越来越多的证据表明,随着年龄的增长钙平衡失调的原因是老年人的维生素D水平不足。在本文中,概述了我们目前对维生素D,其代谢以及与维生素D介导的钙稳态维持有关的机制。此外,与年龄相关的1,25(OH)2D3作用失调有关的机制,建议的每日维生素D和钙剂量,综述了维生素D类似物在骨质疏松症治疗中的应用(仍然存在争议)。阐明维生素D的作用和衰老过程中发生的修饰的分子途径将是未来研究的一个活跃领域,它有可能揭示维持钙平衡的新治疗策略。
更新日期:2019-11-01
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