Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation (CSD) and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control (CON) group. The CSD rats were intervened by a modified multiple platform method (MMPM) to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured. Both the CSD and CON groups had an attenuation of weight gain after 3-month intervention. The plasma glucose level of CSD group was higher than that of the CON group during the IPGTT (P < 0.01). The CSD rats showed a marked increase in HOMA-IR and ITT compared with the CON group (P < 0.01). There were no significant differences of AST, ALT, creatinine, and most lipid parameters between the CSD and CON groups (P > 0.05). The CSD has a marked effect on glucose homeostasis, comprising glucose intolerance and insulin resistance.

中文翻译：

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慢性睡眠剥夺对大鼠葡萄糖稳态的影响

流行病学研究表明，慢性睡眠障碍会导致代谢紊乱。本研究的目的是评估大鼠慢性睡眠剥夺 (CSD) 与葡萄糖稳态之间的关系。24只大鼠随机分为CSD组和对照组（CON）。通过改良的多平台方法（MMPM）对 CSD 大鼠进行干预，以建立慢性睡眠障碍的动物模型。干预3个月后，所有大鼠进行腹腔葡萄糖耐量试验（IPGTT）和胰岛素耐量试验（ITT），体重、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、肌酐、血脂组，并测量了稳态模型评估-IR（HOMA-IR）。在 3 个月的干预后，CSD 和 CON 组的体重增加均有所减弱。IPGTT期间CSD组血糖水平高于CON组（P<0.01）。与CON组相比，CSD大鼠的HOMA-IR和ITT显着增加（P < 0.01）。CSD和CON组的AST、ALT、肌酐和大多数脂质参数没有显着差异（P>0.05）。CSD 对葡萄糖稳态有显着影响，包括葡萄糖耐受不良和胰岛素抵抗。