To examine the role of perceived control in pain perception, fibromyalgia patients and healthy controls participated in a reaction time experiment under different conditions of pain controllability. No significant differences between groups were found in pain intensity and unpleasantness ratings. However, during the expectation of uncontrollable pain, patients compared to controls showed higher hippocampal activation. In addition, hippocampal activity during the pain expectation period predicted activation of the posterior cingulate cortex (PCC), precuneus and hippocampus during pain stimulation in fibromyalgia patients. The increased activation of the hippocampus during pain expectation and subsequent activation of the PCC/precuneus during the lack of control phase points towards an influence of pain perception through heightening of alertness and anxiety responses to pain in fibromyalgia patients.

中文翻译：

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纤维肌痛综合征疼痛预期过程中的可控性和海马激活

为了检查感知控制在疼痛感知中的作用，纤维肌痛患者和健康对照组在不同疼痛可控条件下参与了反应时间实验。组间在疼痛强度和不愉快程度方面没有发现显着差异。然而，在预期无法控制的疼痛期间，与对照组相比，患者表现出更高的海马激活。此外，疼痛预期期间的海马活动预测了纤维肌痛患者在疼痛刺激期间后扣带回皮层 (PCC)、楔前叶和海马的激活。