Recent clinical data have revealed the remarkable potential for T-cell-modulating agents to induce potent and durable responses in a subset of cancer patients. In this review, we discuss molecular approaches, platforms, and strategies that enable a broader interrogation of the activity of agents that modulate the activity of tumor-specific T cells, to more comprehensively understand how and why the agents succeed and fail, as well as examples of data sets generated in clinical trials that have provided important insights into the biological activity of T-cell therapies and that support further rational development of this exciting treatment modality.

中文翻译：

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肿瘤学中 T 细胞治疗的高内涵分子谱分析。

最近的临床数据揭示了 T 细胞调节剂在一部分癌症患者中诱导有效和持久反应的巨大潜力。在这篇综述中，我们讨论了分子方法、平台和策略，这些方法、平台和策略能够更广泛地审视调节肿瘤特异性 T 细胞活性的药物的活性，以更全面地了解药物成功和失败的方式和原因，以及临床试验中生成的数据集的示例提供了对 T 细胞疗法的生物学活性的重要见解，并支持进一步合理开发这种令人兴奋的治疗方式。