当前位置: X-MOL 学术Int. J. Stem Cells › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Unlocking the Neurogenic Potential of Mammalian Müller Glia.
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2016-8-31 , DOI: 10.15283/ijsc16020
Xiaohuan Xia 1 , Iqbal Ahmad 1
Affiliation  

Müller glia (MG) are the primary support cells in the vertebrate retina, regulating homeostasis in one of the most metabolically active tissues. In lower vertebrates such as fish, they respond to injury by proliferating and reprogramming to regenerate retinal neurons. In mammals, MG may also react to injury by proliferating, but they fail to initiate regeneration. The barriers to regeneration could be intrinsic to mammalian MG or the function of the niche that cannot support the MG reprogramming required for lineage conversion or both. Understanding these mechanisms in light of those being discovered in fish may lead to the formulation of strategies to unlock the neurogenic potential of MG and restore regeneration in the mammalian retina.

中文翻译:

释放哺乳动物穆勒胶质细胞的神经源性潜力。

Müller胶质细胞(MG)是脊椎动物视网膜中的主要支持细胞,在代谢最活跃的组织之一中调节体内平衡。在诸如鱼类的低等脊椎动物中,它们通过增殖和重新编程以再生视网膜神经元来对损伤做出反应。在哺乳动物中,MG也可能通过增殖对损伤做出反应,但它们无法引发再生。再生障碍可能是哺乳动物MG固有的,也可能是生态位的功能,而这些生态位不能支持世系转换所需的MG重新编程或两者兼而有之。根据在鱼类中发现的机制来了解这些机制,可能会导致制定一些策略来释放MG的神经源性潜力并恢复哺乳动物视网膜中的再生。
更新日期:2020-08-21
down
wechat
bug