Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also systemically in distant tissues. In our recent publication, we established a “dual system” that induces spatiotemporal tissue damage simultaneously with gene manipulation in surrounding tissues. With this system, we demonstrated that appropriate regulation of methionine metabolism in the fat body is required for tissue repair in Drosophila wing discs, thus highlighting the importance of systemic damage response (SDR) in tissue repair. This “Extra View” aims to discuss our recent reports that propose methionine metabolism to be an essential part of SDR, together with related topics in several model organisms.

活生物体受到周围环境和体内的组织损害。组织修复/再生由局部组织损伤触发，以恢复受伤或丢失的身体部分。组织损伤不仅在局部，而且在远处的组织中均引起一系列反应。在我们最近的出版物中，我们建立了一个“双重系统”，该双重系统在周围组织中进行基因操纵的同时诱导时空组织损伤。通过该系统，我们证明了果蝇翅片的组织修复需要脂肪体内蛋氨酸代谢的适当调节，因此突出了系统损伤反应（SDR）在组织修复中的重要性。本“概观”旨在讨论我们最近的报告，这些报告提出蛋氨酸代谢是SDR的重要组成部分，