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Maternal Care Determinant of Longevity?
Archives Italiennes De Biologie ( IF 1 ) Pub Date : 2016-8-23 , DOI: 10.12871/00039829201613
Marco Giorgio , Chiara Renzi 1 , Serena Oliveri , Gabriella Pravettoni
Affiliation  

Maternal care is an essential early environment in mammals that ensures emotional regulation and adaptive fitness of progeny. Longevity and healthy aging are associated with favorable environmental factors including fitting social and behavioral features. In the present review, we discuss the findings that link rearing conditions and early maternal care with life span and aging from an evolutionary, psychological, and molecular perspective. The quality of maternal care may influence internal adaptation through a variety of parallel mechanisms including emotional regulation, stress sensitivity, coping and other behavioral strategies in response to events requiring adaptation. From a biological perspective, it regulates physiological pathways that may persist in adulthood through epigenetic mechanisms, influencing disease susceptibility and, potentially, longevity. Abnormal maternal care induces maladaptation that persists over the life span, may accelerate the onset of aging associated diseases, and shorten life span. This may have important implications in the development of preventive approaches and early interventions.

中文翻译:

产妇保健长寿的决定因素?

产妇保健是哺乳动物必不可少的早期环境,可确保情绪调节和后代的适应性。长寿和健康的衰老与有利的环境因素相关,包括适合的社会和行为特征。在本综述中,我们从进化论,心理学和分子学的角度讨论了将饲养条件和早期孕产妇保健与寿命和衰老联系起来的发现。孕产妇护理的质量可能通过多种平行机制影响内部适应,包括情绪调节,压力敏感性,应对和其他行为策略,以应对需要适应的事件。从生物学的角度来看,它通过表观遗传机制调节成年后可能持续存在的生理途径,从而影响疾病的易感性,并且 可能长寿。产妇护理异常会导致适应不良,并持续一生,可能会加速衰老相关疾病的发作,并缩短寿命。这可能对预防方法和早期干预措施的发展具有重要意义。
更新日期:2020-08-21
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