Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

中文翻译：

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有效的途径，以不同的氨基醇衍生手性片段的数组。

描述了衍生自手性氨基醇的手性片段的有效合成。可以通过1-5个合成步骤轻松获得几个独特的支架，这些支架可产生45个手性片段，包括恶唑烷酮，吗啉酮，内酰胺和sultams。这些片段的分子量为100至255 Da，可溶于水（0.085至> 15 mM）。