Aerospace/aeronautical thermoset bisphenyl-polymer/carbon-fiber-reinforced composites are considered as new advanced materials to replace metal bone implants. In addition to well-recognized nonpolar chemistry with related bisphenol-polymer estrogenic factors, carbon-fiber-reinforced composites can offer densities and electrical conductivity/resistivity properties close to bone with strengths much higher than metals on a per-weight basis. In vivo bone-marrow tests with Sprague-Dawley rats revealed far-reaching significant osseoconductivity increases from bisphenyl-polymer/carbon-fiber composites when compared to state-of-the-art titanium-6-4 alloy controls. Midtibial percent bone area measured from the implant surface increased when comparing the titanium alloy to the polymer composite from 10.5% to 41.6% at 0.8 mm, , and 19.3% to 77.7% at 0.1 mm, . Carbon-fiber fragments planned to occur in the test designs, instead of producing an inflammation, stimulated bone formation and increased bone integration to the implant. In addition, low-thermal polymer processing allows incorporation of minerals and pharmaceuticals for future major tissue-engineering potential.

中文翻译：

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与钛合金骨植入物相比，联苯聚合物/碳纤维增强复合材料。

航空航天/航空热固性联苯聚合物/碳纤维增强复合材料被视为替代金属骨植入物的新型先进材料。除了公认的具有相关双酚聚合物雌激素因素的非极性化学外，碳纤维增强复合材料还可以提供接近于骨骼的密度和电导率/电阻率特性，其重量比金属强得多。体内用Sprague-Dawley大鼠进行的骨髓测试显示，与最新的6-4钛合金对照组相比，联苯聚合物/碳纤维复合材料的骨电导率具有深远的显着提高。当将钛合金与聚合物复合材料进行比较时，从植入物表面测量的胫骨中骨百分比从0.8 mm处的10.5％增至41.6％，从0.1 mm处的19.3％增至77.7％。计划在测试设计中出现的碳纤维碎片不会产生发炎，刺激骨形成并增加了与植入物的骨整合。另外，低热聚合物加工允许掺入矿物质和药物，以用于未来的主要组织工程潜力。