In the past two decades, several newly emerging and reemerging viral respiratory pathogens including several influenza viruses (avian influenza and pandemic influenza), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (MERS-CoV), have continued to challenge medical and public health systems. Thereafter, the development of cost-effective, broad-spectrum antiviral agents is the urgent mission of both virologists and pharmacologists. Current antiviral developments have focused targets on viral entry, replication, release, and intercellular pathways essential for viral life cycle. Here, we review the current literature on challenges and prospects in the development of these antivirals.

中文翻译：

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呼吸道病毒感染的抗病毒药物：问题和前景。

在过去的二十年中，已经出现了几种新出现和重新出现的病毒呼吸道病原体，包括几种流感病毒（禽流感和大流行性流感），严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）。继续挑战医疗和公共卫生系统。此后，开发具有成本效益的广谱抗病毒药物是病毒学家和药理学家的紧迫任务。当前的抗病毒开发已将目标集中在病毒生命周期必不可少的病毒进入，复制，释放和细胞间途径上。在这里，我们回顾了有关这些抗病毒药物开发中的挑战和前景的最新文献。