SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter-specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.

中文翻译：

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SoxD转录因子：神经发育的多方面参与者。

SoxD转录因子亚家族包括三个成员，即Sox5，Sox6和Sox13。像其他Sox基因一样，它们包含高迁移率族（HMG）框作为DNA结合结构域，但另外具有亚组特异性亮氨酸拉链基序。SoxD基因在胚胎发生期间和成年期在多种器官的多种细胞类型中表达。表达它们的细胞是存在于发育中的神经系统中的那些细胞，包括神经干细胞（或祖细胞）以及分化神经元和少突胶质细胞。SoxD转录因子不包含独特的激活子或阻遏物结构域，并且据信它们在启动子特异性方式的其他转录因子的调节中起作用。