Recent models of schizophrenia suggest deficient use of contextual response cues when confronted with countermanding emotional cues. It is important to clinically validate these models by testing patients diagnosed with schizophrenia on tasks with competing emotional and contextual response determinants. Control and schizophrenia groups completed a novel task that elicited motor responses consistent with, or in opposition to, pre‐potent emotional actions (i.e., approach vs. avoidance). An analogous non‐emotional task was also used to examine cue‐conflict impairment more generally. The groups demonstrated statistically equivalent performance decrements on incongruent versus congruent trials on both tasks. However, within the schizophrenia group, the incongruency effect was significantly greater in the emotional versus non‐emotional task. These data suggest that, while patients with schizophrenia were able to employ contextual response cues to override competing emotional responses, they were slower to resolve emotional versus non‐emotional response conflict. When patients were subdivided according to the presence or absence of disorganized symptoms, this effect was confined to patients with disorganized symptoms.

中文翻译：

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在精神分裂症中抑制对情绪和非情绪反应线索的反应：来自运动过程范式的见解。

精神分裂症的最新模型表明，面对反抗情绪线索时，上下文响应线索的使用不足。通过测试诊断为精神分裂症的患者在竞争性情感和情境反应决定因素的任务上，对这些模型进行临床验证非常重要。对照和精神分裂症小组完成了一项新颖的任务，该运动引起与有力的情绪行为相一致或相反的运动反应（即进场与回避）。类似的非情感任务也被用来更广泛地检查提示冲突。这些组在两项任务的不一致试验和一致试验中均显示出统计学上等效的性能下降。然而，在精神分裂症组中，情感和非情感任务的不一致效果明显更大。这些数据表明，尽管精神分裂症患者能够采用情境反应提示来替代竞争性情绪反应，但他们解决情绪与非情绪反应冲突的速度较慢。当根据是否存在紊乱症状将患者细分时，这种作用仅限于症状紊乱的患者。