IL-33 is a multifunctional cytokine that is released in response to a variety of intrinsic and extrinsic stimuli. The role of IL-33 in Candida albicans infections is just beginning to be revealed. This cytokine has beneficial effects on host defense against systemic C. albicans infections, and it promotes resistance mechanisms by which the immune system eliminates the invading fungal pathogens; and it also elevates host tolerance by reducing the inflammatory response and thereby, potentially, tissue damage. Thus, IL-33 is classified as a cytokine that has evolved functionally to protect the host from damage by pathogens and immunopathology.

中文翻译：

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IL-33 在抵抗和耐受全身性白色念珠菌感染中的作用

IL-33 是一种多功能细胞因子，可响应各种内在和外在刺激而释放。IL-33 在白色念珠菌感染中的作用才刚刚开始被揭示。这种细胞因子对宿主防御全身性白色念珠菌感染具有有益作用，并促进免疫系统消除入侵真菌病原体的抵抗机制；它还通过减少炎症反应来提高宿主的耐受性，从而潜在地减少组织损伤。因此，IL-33 被归类为一种细胞因子，其功能进化以保护宿主免受病原体和免疫病理学的损害。