Cellular therapies using Mesenchymal Stem Cells (MSCs) represent a promising approach for the treatment of degenerative diseases, in particular for mesengenic tissue regeneration. However, before the approval of clinical trials in humans, in vitro studies must be performed aimed at investigating MSCs' biology and the mechanisms regulating their proliferation and differentiation abilities. Besides studies on human MSCs (hMSCs), MSCs derived from rodents have been the most used cellular type for in vitro studies. Nevertheless, the transfer of the results obtained using animal MSCs to hMSCs has been hindered by the limited knowledge regarding the similarities existing between cells of different origins. Aim of this paper is to highlight similarities and differences and to clarify the sometimes reported different results obtained using these cells.

中文翻译：

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致生分化：人和大鼠骨髓间充质干细胞的比较。

使用间充质干细胞（MSC）的细胞疗法代表了一种治疗退行性疾病，特别是用于间质性组织再生的有前途的方法。但是，在批准用于人体的临床试验之前，必须进行旨在研究MSC生物学以及调节其增殖和分化能力的机制的体外研究。除了对人类MSC（hMSC）的研究以外，从啮齿类动物衍生的MSC已成为体外研究中使用最多的细胞类型。然而，由于关于不同来源的细胞之间存在的相似性的有限知识，已经阻碍了使用动物MSC获得的结果向hMSC的转移。本文的目的是强调相似性和差异性，并阐明有时报告的使用这些电池获得的不同结果。