BACKGROUND Since the first successful use of donated oocytes in 1984, the number of oocyte donation cycles in Europe and the USA has dramatically increased. Consequently, there has been increasing interest in the impact of oocyte donation on maternal and fetal outcomes. OBJECTIVE AND RATIONALE The aim of this review was to summarize the literature regarding maternal and fetal outcomes from pregnancies conceived through oocyte donation. SEARCH METHODS Identification of relevant publications was through research within the Embase Medline and PubMed databases, the Google-indexed scientific literature and periodic specialized magazines from the on-line Library Service of the University of Milan. OUTCOMES Oocyte donation seems to be independently associated with a higher rate of pregnancy-induced hypertension and pre-eclampsia. An explanatory hypothesis is that an immunological maladaptation causes placenta-mediated disorders in oocyte donation pregnancies. The risks are even higher in twin pregnancies. Oocyte donation also seems to be associated with lower fetal birthweight. However, after adjusting for obstetric complications, most studies report less pronounced differences in birthweight or no dissimilarities. The incidence of cesarean section is increased without clear clinical indications. WIDER IMPLICATIONS Oocyte donation pregnancies are associated with a higher rate of placental disorders of pregnancy, such as gestational hypertension and pre-eclampsia. The risk of poorer neonatal outcomes is increased in oocyte donation pregnancies compared to other in-vitro fertilization pregnancies. Poorer outcomes have been demonstrated especially for twin pregnancies and in association with previous chronic pathologies or the development of obstetrics complications.

中文翻译：

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卵母细胞捐赠妊娠中的母体和胎儿结局。

背景技术自1984年首次成功使用捐赠的卵母细胞以来，欧洲和美国的卵母细胞捐赠周期数量急剧增加。因此，人们对卵母细胞捐赠对母亲和胎儿结局的影响越来越感兴趣。目的和理由本综述旨在总结有关通过卵母细胞受孕而产生的母婴结果的文献。搜索方法通过在Embase Medline和PubMed数据库，谷歌索引的科学文献以及米兰大学在线图书馆服务的定期专业杂志中进行研究，确定相关出版物。结果卵母细胞捐赠似乎与妊娠高血压病和先兆子痫的发生率高有关。一个解释性的假设是，免疫性适应不良会导致卵母细胞捐赠妊娠中胎盘介导的疾病。双胎妊娠的风险更高。卵母细胞捐赠似乎也与胎儿出生体重降低有关。但是，在调整了产科并发症后，大多数研究报告出生体重的差异不太明显或没有差异。没有明确的临床指征，剖宫产的发生率会增加。对胎儿的影响卵母细胞捐赠妊娠与妊娠胎盘疾病（例如妊娠高血压和先兆子痫）的发生率较高有关。与其他体外受精妊娠相比，卵子捐献妊娠新生儿不良结局的风险增加。