Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3. Dot1 was initially identified by a genetic screen as a disruptor of telomeric silencing in Saccharomyces cerevisiae; further, it is the only known non-SET domain containing histone methyltransferase. Methylation of H3K79 is involved in the regulation of telomeric silencing, cellular development, cell-cycle checkpoint, DNA repair, and regulation of transcription. hDot1L-mediated H3K79 methylation appears to have a crucial role in transformation as well as disease progression in leukemias involving several oncogenic fusion proteins. This review summarizes the multiple functions of Dot1/hDOT1L in a range of cellular processes.

中文翻译：

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组蛋白H3K79甲基化的许多面孔。

Dot1 / DOT1L（端粒沉默-1的破坏者）是进化上保守的组蛋白甲基转移酶，可甲基化位于组蛋白H3球状结构域内的赖氨酸79。最初通过遗传筛选将Dot1鉴定为酿酒酵母端粒沉默的破坏者。此外，它是唯一已知的包含组蛋白甲基转移酶的非SET结构域。H3K79的甲基化与端粒沉默，细胞发育，细胞周期检查点，DNA修复和转录调控有关。hDot1L介导的H3K79甲基化似乎在涉及多种致癌融合蛋白的白血病的转化以及疾病进展中具有至关重要的作用。这篇综述总结了Dot1 / hDOT1L在一系列细胞过程中的多种功能。