Fluctuation correlation spectroscopy (FCS) is a well-established analytical technique traditionally used to monitor molecular diffusion in dilute solutions, the dynamics of chemical reactions, and molecular processes inside living cells. In this review, we present the recent use of FCS for measuring the size of colloidal nanoparticles in solution. We review the theoretical basis and experimental implementation of this technique and its advantages and limitations. In particular, we show examples of the use of FCS to measure the size of gold nanoparticles, monitor the rotational dynamics of gold nanorods, and investigate the formation of protein coronas on nanoparticles.

中文翻译：

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使用涨落相关光谱法测量纳米颗粒的流体动力学尺寸。

波动相关光谱（FCS）是一种建立完善的分析技术，传统上用于监测稀溶液中的分子扩散，化学反应的动力学以及活细胞内的分子过程。在这篇综述中，我们介绍了FCS在测量溶液中胶体纳米颗粒尺寸方面的最新用途。我们回顾了这项技术的理论基础和实验实施及其优势和局限性。特别是，我们展示了使用FCS来测量金纳米粒子的大小，监控金纳米棒的旋转动力学以及研究纳米粒子上蛋白质电晕形成的示例。