We report here on the development of a method for inducing a stroke in a specific location within a mouse brain through the use of an optical fiber. By capturing the emitted fluorescence signal generated using the same fiber it is possible to monitor photochemical changes within the brain in real-time, and directly measure the concentration of the stroke-inducing dye, Rose Bengal, at the infarct site. This technique reduces the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal, and therefore opens up the opportunity to explore the recovery of the brain after the stroke event.

中文翻译：

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使用光纤生成和测量大脑内部的光化学变化：探索中风。

我们在这里报告了一种通过使用光纤在小鼠脑内特定位置诱发中风的方法的开发。通过捕获使用同一根光纤产生的发出的荧光信号，可以实时监控大脑中的光化学变化，并直接在梗塞部位测量诱发中风的染料Rose Bengal的浓度。这项技术减少了术后组织学检查以确定在动物内是否成功诱发中风的需要，因此为中风事件后探索大脑的恢复提供了机会。