Neopeltolide, isolated in 2007, with its novel structural features and potent anti cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each of the synthesis with the main focus on the strategies and methodologies for the construction of its cis-tetrahydropyran-containing macrolactone core.

中文翻译：

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合成抗癌天然产物 Neopeltolide 及其类似物的策略和方法

Neopeltolide 于 2007 年分离，具有新颖的结构特征和有效的抗癌细胞增殖活性，吸引了大量的合成努力。本综述简要并按时间顺序总结了每个合成，主要关注构建其含顺式四氢吡喃的大环内酯核心的策略和方法。