Recent advances in molecular imaging and nanotechnology are providing new opportunities for biomedical imaging with great promise for the development of novel imaging agents. The unique optical, magnetic, and chemical properties of materials at the scale of nanometers allow the creation of imaging probes with better contrast enhancement, increased sensitivity, controlled biodistribution, better spatial and temporal information, multi-functionality and multi-modal imaging across MRI, PET, SPECT, and ultrasound. These features could ultimately translate to clinical advantages such as earlier detection, real time assessment of disease progression and personalized medicine. However, several years of investigation into the application of these materials to cancer research has revealed challenges that have delayed the successful application of these agents to the field of biomedical imaging. Understanding these challenges is critical to take full advantage of the benefits offered by nano-sized imaging agents. Therefore, this article presents the lessons learned and challenges encountered by a group of leading researchers in this field, and suggests ways forward to develop nanoparticle probes for cancer imaging. Published by Elsevier Ltd.

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用于癌症成像的纳米粒子：好的、坏的和前景

分子成像和纳米技术的最新进展为生物医学成像提供了新的机会，为开发新型成像剂带来了巨大希望。纳米级材料的独特光学、磁性和化学性质允许创建具有更好对比度增强、更高灵敏度、受控生物分布、更好的空间和时间信息、多功能和跨 MRI 多模态成像的成像探针， PET、SPECT 和超声波。这些特征最终可以转化为临床优势，例如早期检测、疾病进展的实时评估和个性化医疗。然而，对这些材料在癌症研究中的应用进行的几年调查揭示了一些挑战，这些挑战推迟了这些试剂在生物医学成像领域的成功应用。了解这些挑战对于充分利用纳米级显像剂的优势至关重要。因此，本文介绍了该领域领先研究人员的经验教训和遇到的挑战，并提出了开发用于癌症成像的纳米粒子探针的方法。由爱思唯尔有限公司出版。并提出了开发用于癌症成像的纳米粒子探针的方法。由爱思唯尔有限公司出版。并提出了开发用于癌症成像的纳米粒子探针的方法。由爱思唯尔有限公司出版。