In the target article, Vaidyanathan, Vrieze and Iacono reflect on the lack of advancement in our etiologic understanding of psychopathology. They persuasively argue that theory-guided integrative research, due to its targeted testing of putative mechanisms, should be prioritized. Through a comprehensive narrative, and drawing elegantly on a vast body of endophenotype research, these authors suggest that “risky tests” of causal theories (i.e., a test that narrows the number of causal interpretations available) offer the most potential to inform our understanding of psychopathology. In addition, the authors point out that statistics and technology, when haphazardly applied, can have perilous consequences. They advocate, instead for risky study designs that are guided by a strong theoretical basis, are free of diagnostic boundaries and fueled by knowledge from multiple research domains. We could not agree more with their proposal.

中文翻译：

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风险业务：精神病理学生物信息研究进展的途径

在目标文章中，Vaidyanathan、Vrieze 和 Iacono 反思了我们对精神病理学的病因学理解缺乏进步。他们有说服力地认为，由于其对假定机制的有针对性的测试，应该优先考虑以理论为指导的综合研究。通过全面的叙述，并优雅地借鉴了大量的内表型研究，这些作者认为因果理论的“风险测试”（即缩小可用因果解释数量的测试）最有可能让我们了解精神病理学。此外，作者指出，如果随意应用统计和技术，可能会产生危险的后果。他们提倡，而不是以强有力的理论基础为指导的风险研究设计，没有诊断边界，并由来自多个研究领域的知识推动。我们完全同意他们的提议。