After the sensational rediscovery of living exemplars of the Cretaceous relict Metasequoia glyptostroboides-a tree previously known exclusively from fossils from various locations in the northern hemisphere, there has been an increasing interest in discovery of novel natural products from this unique plant source. This article includes the first complete compilation of natural products reported from M. glyptostroboides during the entire period in which the tree has been investigated (1954-2014) with main focus on the compounds specific to this plant source. Studies on the biological activity of pure compounds and extracts derived from M. glyptostroboides are reviewed for the first time. The unique potential of M. glyptostroboides as a source of bioactive constituents is founded on the fact that the tree seems to have survived unchanged since the Cretaceous era. Since then, its molecular defense system has resisted the attacks of millions of generations of pathogens. In line with this, some recent landmarks in Metasequoia paleobotany are covered. Initial spectral analysis of recently discovered intact 53 million year old wood and amber of Metasequoia strongly indicate that the tree has remained unchanged for millions of years at the molecular level.

中文翻译：

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与恐龙一起成长：白垩纪遗物水杉（Museusquoia glyptostroboides Hu＆Cheng）的天然产物-来自古代世界的分子库，具有现代医学潜力。

在轰动性地重新发现了白垩纪遗物水杉后代（以前仅从北半球各个位置的化石中得知的一棵树）的活生生的例子之后，人们越来越有兴趣从这种独特的植物来源中发现新颖的天然产物。本文包括在整个树木调查期间（1954-2014年）报道的从拟南芥（M. glyptostroboides）报道的天然产物的第一份完整汇编，主要侧重于对该植物来源特有的化合物。首次综述了来自糖脂单胞菌的纯化合物和提取物的生物活性的研究。M的独特潜力。glyptostroboides作为生物活性成分的来源是基于这样的事实，即该树自白垩纪时代以来似乎一直未变。从那时起，其分子防御系统就抵抗了数百万代病原体的攻击。与此相应，本文涵盖了水杉古植物园的一些近期地标。对最近发现的完整的5300万年前的木材和水杉的琥珀进行的初步光谱分析强烈表明，该树在分子水平上保持了数百万年的不变。