BackgroundThe effect of moderately elevated blood glucose levels among non-diabetic subjects on cancer prognosis is not well described. The goal of this study was to examine the association of elevated random blood glucose (RBG) levels in non-diabetic breast cancer patients with overall survival (OS) and time to tumor recurrence (TTR).ResultsForty-nine deaths and 32 recurrences occurred among 148 eligible study subjects during 855.44 person-years of follow-up, with median follow-up of 5.97 years. We observed that patients with elevated RBG levels experienced significantly shorter OS (hazard ratio [HR], 3.01; 95 % confidence interval [CI] (1.70–5.33); P < 0.001) and shorter TTR (HR, 2.08; CI (1.04–4.16); P = 0.04) as compared to patients with non-elevated RBG levels. After controlling for tumor grade, tumor stage, race, and BMI, elevated RBG continued to display high and statistically significant association with shorter OS (HR, 3.50; CI (1.87–6.54); P < 0.001). Adjustment for age, race, and BMI strengthened HR of RBG for TTR. The association of RGB with TTR lost its borderline statistical significance upon controlling for both tumor grade and stage.ConclusionsThe data suggest that elevated blood glucose is associated with poor prognosis of breast cancer patients. Given the potential clinical implication, these findings warrant further investigation.

中文翻译：

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乳腺癌女性的诊断前血糖和预后

背景未充分描述非糖尿病受试者中适度升高的血糖水平对癌症预后的影响。本研究的目的是检查非糖尿病乳腺癌患者随机血糖 (RBG) 水平升高与总生存期 (OS) 和肿瘤复发时间 (TTR) 之间的关联。结果 49 例死亡和 32 例复发在 855.44 人年的随访期间，148 名符合条件的研究对象，中位随访时间为 5.97 年。我们观察到 RBG 水平升高的患者经历了显着更短的 OS（风险比 [HR]，3.01；95% 置信区间 [CI]（1.70-5.33）；P < 0.001）和更短的 TTR（HR，2.08；CI（1.04-） 4.16)；P = 0.04) 与 RBG 水平未升高的患者相比。在控制了肿瘤分级、肿瘤分期、种族和 BMI 后，升高的 RBG 继续显示出与较短 OS 的高度和统计学显着相关性（HR，3.50；CI（1.87-6.54）；P < 0.001）。年龄、种族和 BMI 的调整增强了 RBG 对 TTR 的 HR。在控制肿瘤分级和分期后，RGB 与 TTR 的关联失去了其临界统计显着性。结论 数据表明，血糖升高与乳腺癌患者的不良预后相关。鉴于潜在的临床意义，这些发现值得进一步调查。结论 数据表明，血糖升高与乳腺癌患者的不良预后有关。鉴于潜在的临床意义，这些发现值得进一步调查。结论 数据表明，血糖升高与乳腺癌患者的不良预后有关。鉴于潜在的临床意义，这些发现值得进一步调查。