The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors that promote longevity in laboratory setting often have severe fitness disadvantage in the wild. Here, to obtain an unbiased view on longevity regulation we analyzed how replicative lifespan is shaped by transcriptional, translational, metabolic, and morphological factors across 22 wild-type Saccharomyces cerevisiae isolates. We observed significant differences in lifespan across these strains and found that their longevity is strongly associated with up-regulation of oxidative phosphorylation and respiration and down-regulation of amino acid and nitrogen compound biosynthesis. Since calorie restriction and TOR signaling also extend lifespan by adjusting many of the identified pathways, the data suggest that natural plasticity of yeast lifespan is shaped by processes that not only do not impose cost on fitness, but are amenable to dietary intervention.

中文翻译：

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定义天然酵母分离物中长寿性状的分子基础。

发芽的酵母已成为衰老研究中的有用模式生物，导致长寿遗传决定因素的鉴定，其中许多在高等真核生物中是保守的。但是，在实验室环境中延长寿命的因素通常在野外严重不利于健身。在这里，为了获得对寿命调节的公正看法，我们分析了跨22种野生型酿酒酵母菌株的转录，翻译，代谢和形态因素如何影响复制寿命。我们观察到这些菌株的寿命存在显着差异，并且发现它们的寿命与氧化磷酸化和呼吸作用的上调以及氨基酸和氮化合物生物合成的下调密切相关。