The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members of the cullin RING ligase superfamily. Cul5-type ubiquitin ligases have a variety of substrates that are targeted for polyubiquitination and proteasomal degradation. Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.

中文翻译：

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含cullin 5的泛素连接酶的作用。

细胞因子信号转导抑制因子（SOCS）盒由BC盒和cullin 5（Cul5）盒组成，它们分别与Elongin BC和Cul5相互作用。包含SOCS盒的蛋白质具有通过与支架蛋白Cul5和RING结构域蛋白Rbx2形成复合物而介导的遍在蛋白连接酶活性，因此是cullin RING连接酶超家族的成员。Cul5型泛素连接酶具有多种针对多泛素化和蛋白酶体降解的底物。在这里，我们回顾了有关Cul5的鉴定及其表达调控的当前知识，以及由Cul5调控的信号传导途径，以及病毒如何劫持Cul5系统以克服抗病毒反应。