Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly concentrating on Rrp47. This review will look to reconcile the functions of these proteins in their involvement with the RNA exosome, in the regulation of chromatin architecture, and in the repair of DNA double-strand breaks, focusing on non-homologous end joining and homologous recombination. We propose that C1D is situated in a central position to maintain genomic stability at highly transcribed gene loci by coordinating these processes through the timely recruitment of relevant regulatory factors. In the event that the damage is beyond repair, C1D induces apoptosis in a p53-dependent manner.

中文翻译：

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C1D家族蛋白可协调RNA加工，染色体浓缩和DNA损伤反应。

C1D及其酵母同源物Rrp47（S. cerevisiae）和Cti1（S. pombe）在DNA损伤修复和RNA处理中的参与研究仍然相互排斥，大多数研究主要集中在Rrp47上。这项审查将寻求调和这些蛋白质在参与RNA外泌体，染色质结构调节和DNA双链断裂修复中的功能，重点是非同源末端连接和同源重组。我们建议C1D处于中心位置，可通过及时募集相关的调控因子来协调这些过程，从而在高度转录的基因位点维持基因组稳定性。如果损害无法修复，C1D会以p53依赖的方式诱导细胞凋亡。