The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. The malaria field is gaining new opportunities from this important breakthrough and novel tools were adapted and opened new frontiers for malaria research. In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models.

中文翻译：

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疟疾模型：体外干细胞与体内模型。

干细胞研究的最新进展以及产生可在其基因组中稳定和永久修饰的细胞的可能性为体外建模世界开辟了广阔的前景。疟疾领域正从这一重要突破中获得新的机遇，并采用了新颖的工具，为疟疾研究开辟了新的领域。除了新的体外系统，近年来，在开发新的动物模型方面也取得了重大进展，该模型可以研究人类疟疾的整个细胞周期。在本文中，我们回顾了可通过使用干细胞或其他动物模型研究人类疟原虫物种的不同协议。