Combinations of leukocyte attractant ligands and cognate heptahelical receptors specify the systemic recruitment of circulating cells by triggering integrin-dependent adhesion to endothelial cells, supporting extravasation, and directing specific intratissue localization via gradient-driven chemotaxis. Chemoattractant receptors also control leukocyte egress from lymphoid organs and peripheral tissues. In this article, we summarize the fundamental mechanics of leukocyte trafficking, from the evolution of multistep models of leukocyte recruitment and navigation to the regulation of chemoattractant availability and function by atypical heptahelical receptors. To provide a more complete picture of the migratory circuits involved in leukocyte trafficking, we integrate a number of nonchemokine chemoattractant receptors into our discussion. Leukocyte chemoattractant receptors play key roles in the pathogenesis of autoimmune diseases, allergy, inflammatory disorders, and cancer. We review recent advances in our understanding of chemoattractant receptors in disease pathogenesis, with a focus on genome-wide association studies in humans and the translational implications of mechanistic studies in animal disease models.

中文翻译：

---

白细胞趋化因子受体在人类疾病的发病机理中。

白细胞引诱剂配体和同源的七螺旋受体的组合通过触发整合素依赖性内皮细胞粘附，支持外渗并通过梯度驱动趋化性指导特定的组织内定位，从而指定了循环细胞的系统募集。趋化因子受体还控制白细胞从淋巴器官和周围组织流出。在本文中，我们总结了白细胞运输的基本机理，从白细胞募集和导航的多步模型的演化到非典型七​​螺旋受体对化学引诱剂可用性和功能的调节。为了提供有关白细胞贩运的迁移回路的更完整描述，我们将许多非趋化因子趋化因子受体整合到我们的讨论中。白细胞趋化因子受体在自身免疫性疾病，过敏，炎症性疾病和癌症的发病机理中起关键作用。我们回顾了对疾病发病机理中趋化因子受体的了解的最新进展，重点是人类的全基因组关联研究以及动物疾病模型中机理研究的转化意义。