The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.

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治疗内皮疾病的纳米药物

内皮细胞排列在血管和淋巴管的内表面上，在维持体内平衡方面发挥着关键作用。内皮功能障碍涉及许多疾病和病症的病理学，包括糖尿病、心血管疾病和癌症等病症。鉴于一系列疾病的常见病因，针对受损内皮的药物可以增强治疗方法。纳米医学——纳米技术在医疗保健中的应用——为治疗与内皮受损相关的疾病提供了新的机会和潜力。这篇综述讨论了目前可用于治疗这些疾病的疗法，并重点介绍了纳米医学在治疗这些主要疾病并发症中的应用。