GRAPHICAL ABSTRACT Abstract Zwitterionic materials are useful tools in material science and biology as they provide high water solubility while preventing nonspecific interactions. Quantum dots (QDs) functionalized with zwitterionic and quaternary ammonium ligands were synthesized to investigate their interactions with the outer membrane of HeLa cells. Quaternary ammonium functionalized quantum dots adhered strongly to the cell surface while zwitterionic QDs had no cell adhesion. These results demonstrate that future noninteracting nanoparticles based on this design are possible.

中文翻译：

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与 Cdse/Zns 量子点结合的两性离子配体可防止与哺乳动物细胞粘附

图形摘要摘要两性离子材料是材料科学和生物学中的有用工具，因为它们提供高水溶性，同时防止非特异性相互作用。合成了用两性离子和季铵配体功能化的量子点 (QD)，以研究它们与 HeLa 细胞外膜的相互作用。季铵功能化量子点牢固地粘附在细胞表面，而两性离子量子点没有细胞粘附。这些结果表明，基于这种设计的未来非相互作用纳米粒子是可能的。