Natural or synthetic chalcones with different substituents have revealed a variety of biological activities that may benefit human health. The underlying mechanisms of action, particularly with respect to the direct cellular targets and the modes of interaction with the targets, have not been rigorously characterized, which imposes challenges to structure-guided rational development of therapeutic agents or chemical probes with acceptable target-selectivity profile. This review summarizes literature evidence on chalcones' direct molecular targets in the context of their biological activities.

中文翻译：

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具有不同生物活性的查耳酮的多种分子靶标。

具有不同取代基的天然或合成查耳酮已揭示出各种可能有益于人类健康的生物活性。尚未明确表征潜在的作用机制，尤其是针对直接细胞靶标以及与靶标相互作用的方式，这对具有可接受的靶标选择性特征的治疗剂或化学探针的结构指导的合理开发提出了挑战。这篇综述总结了有关查耳酮的直接分子靶标在其生物学活性方面的文献证据。