The biogenic amines dopamine and serotonin are neurotransmitters and hormones, which are mainly produced in the central nervous system and in the gastro-intestinal tract. They execute local and systemic functions such as intestinal motility and tissue repair. Dopamine and serotonin are primarily stored in and transported by platelets. This review focuses on the recently recognized role of dopamine and serotonin in the regulation of tumor behavior by affecting angiogenesis and tumor cell proliferation. Preclinical studies demonstrate that dopamine inhibits tumor growth via activation of dopamine receptor D2 on endothelial and tumor cells. Serotonin stimulates tumor growth via activation of serotonin receptor 2B on endothelial cells and serotonin receptors on tumor cells. Drugs that stimulate dopamine receptor D2 or inhibit serotonin receptors are available and therefore clinical intervention studies for cancer patients are within reach.

中文翻译：

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多巴胺和5-羟色胺通过影响血管生成来调节肿瘤行为。

生物胺多巴胺和5-羟色胺是神经递质和激素，主要在中枢神经系统和胃肠道中产生。它们执行局部和全身功能，例如肠蠕动和组织修复。多巴胺和5-羟色胺主要储存在血小板中并通过血小板运输。这篇综述着重于最近认识到多巴胺和5-羟色胺通过影响血管生成和肿瘤细胞增殖而在调节肿瘤行为中的作用。临床前研究表明，多巴胺通过激活内皮细胞和肿瘤细胞上的多巴胺受体D2抑制肿瘤生长。5-羟色胺通过激活内皮细胞上的5-羟色胺受体2B和肿瘤细胞上的5-羟色胺受体来刺激肿瘤生长。