BackgroundAtopic dermatitis constitutes a most burdensome chronic inflammatory skin disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only insufficiently.FindingsRecent advances in our understanding of the role of histamine and its four receptors suggest new approaches which target the histamine receptors alone or as combination therapies to more efficiently combat pruritus and inflammation in atopic dermatitis.ConclusionsWith this review, we provide an overview on histamine and the expression of its four receptors on skin resident and nonresident cells. Furthermore, we summarize recent studies which suggest anti-histamine therapy to efficiently combat pruritus and inflammation in atopic dermatitis and discuss possible approaches to incorporate these findings into more effective treatment strategies for atopic dermatitis in childhood.

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组胺及其受体在特应性皮炎中的表达及功能

背景特应性皮炎是一种最严重的慢性炎症性皮肤病。标准治疗很麻烦，而且往往针对其主要症状，瘙痒，但仅不够充分。研究结果我们对组胺及其四种受体作用的理解的最新进展表明，新方法可以单独靶向组胺受体或作为联合疗法更有效地对抗瘙痒和炎症在特应性皮炎中。结论通过这篇综述，我们概述了组胺及其四种受体在皮肤驻留细胞和非驻留细胞上的表达。此外，