The potential use of stem cell based therapies for the repair and regeneration of various tissues offers a paradigm shift that may provide alternative therapeutic solutions for a number of diseases. The use of either embryonic stem cells (ESCs) or induced pluripotent stem cells in clinical situations is limited due to cell regulations and to technical and ethical considerations involved in genetic manipulation of human ESCs, even though these cells are highly beneficial. Mesenchymal stem cells seen to be an ideal population of stem cells in particular, Adipose derived stem cells (ASCs) which can be obtained in large number and easily harvested from adipose tissue. It is ubiquitously available and has several advantages compared to other sources as easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose derived mesenchymal stem cells yield a high amount of stem cells which is essential for stem cell based therapies and tissue engineering. Recently, periodontal tissue regeneration using ASCs has been examined in some animal models. This method has potential in the regeneration of functional periodontal tissues because various secreted growth factors from ASCs might not only promote the regeneration of periodontal tissues but also encourage neovascularization of the damaged tissues. This review summarizes the sources, isolation and characteristics of adipose derived stem cells and its potential role in periodontal regeneration is discussed.

中文翻译：

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脂肪组织-足够的可及再生材料。

基于干细胞的疗法在各种组织的修复和再生中的潜在用途提供了范式转变，可以为多种疾病提供替代的治疗方案。由于细胞法规以及涉及人类胚胎干细胞基因操作的技术和道德考虑，在临床情况下，胚胎干细胞（ESC）或诱导多能干细胞的使用受到限制，即使这些细胞非常有益。间充质干细胞被认为是理想的干细胞群体，尤其是脂肪来源的干细胞（ASC），可以大量获得并易于从脂肪组织中收获。与其他来源相比，该工具无处不在，并且具有多种优势，因为使用最少的侵入式收割程序就可以轻松地进行大量获取，脂肪来源的间充质干细胞的分离和分离产生了大量的干细胞，这对于基于干细胞的疗法和组织工程至关重要。最近，在一些动物模型中已经检查了使用ASC的牙周组织再生。该方法在功能性牙周组织的再生中具有潜力，因为来自ASC的各种分泌的生长因子不仅可以促进牙周组织的再生，而且可以促进受损组织的新生血管形成。这篇综述总结了脂肪干细胞的来源，分离和特性，并讨论了其在牙周再生中的潜在作用。在某些动物模型中已经检查了使用ASC进行牙周组织再生的情况。该方法在功能性牙周组织的再生中具有潜力，因为来自ASC的各种分泌的生长因子不仅可以促进牙周组织的再生，而且可以促进受损组织的新血管形成。这篇综述总结了脂肪干细胞的来源，分离和特征，并讨论了其在牙周再生中的潜在作用。在某些动物模型中已经检查了使用ASC进行牙周组织再生的情况。该方法在功能性牙周组织的再生中具有潜力，因为来自ASC的各种分泌的生长因子不仅可以促进牙周组织的再生，而且可以促进受损组织的新血管形成。这篇综述总结了脂肪干细胞的来源，分离和特性，并讨论了其在牙周再生中的潜在作用。