Nanomaterials have an advantage in "personalized" therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray diffraction; transmission electron microscopy, Physical Property Measurement System, and Fourier transform infrared spectroscopy. The cytotoxicity of FePt NPs on Vero cells was assessed using an MTT assay, and tumor cell proliferation inhibited by individual FePt NPs and FePt NPs combined with X-ray beams were also collected using MTT assays; HeLa human cancer cell lines were used as in vitro models. Further confirmation of the combined effect of FePt NPs and X-rays was verified using HeLa cells, after which, the cellular uptake of FePt NPs was captured by transmission electron microscopy. The results indicated that the growth of HeLa cells was significantly inhibited by FePt NPs in a concentration-dependent manner, and the growth was significantly more inhibited by FePt NPs combined with a series of X-ray beam doses; the individual NPs did not display any remarkable cytotoxicity on Vero cells at a concentration <250 μg/mL. Meanwhile, the FePt NPs showed negative/positive contrast enhancement for MRI/CT molecule imaging at the end of the study. Therefore, the combined results implied that FePt NPs might potentially serve as a promising nanoprobe for the integration of tumor diagnosis and chemoradiotherapy.

中文翻译：

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FePt纳米颗粒可作为HeLa细胞的潜在X射线活化化学治疗剂。

纳米材料在“个性化”治疗中具有优势，这是肿瘤治疗的最终目标。为了研究FePt纳米颗粒（NPs）在恶性肿瘤的诊断和放化疗中的潜在能力，使用半胱胺作为封端剂，合成了超顺磁性，单分散的FePt（〜3 nm）合金NPs。NP通过X射线衍射表征。透射电子显微镜，物理性质测量系统和傅立叶变换红外光谱。用MTT测定法评估FePt NPs对Vero细胞的细胞毒性，并用MTT测定法收集被单独的FePt NPs和FePt NPs与X射线束结合抑制的肿瘤细胞增殖。HeLa人癌细胞系用作体外模型。使用HeLa细胞进一步证实了FePt NP和X射线的联合作用，此后，通过透射电子显微镜捕获了FePt NPs的细胞摄取。结果表明，FePt NPs以浓度依赖的方式显着抑制HeLa细胞的生长，而FePt NPs结合一系列X射线剂量对HeLa细胞的生长具有明显的抑制作用。单个NP在<250μg/ mL的浓度下对Vero细胞无任何明显的细胞毒性。同时，在研究结束时，FePt NP对MRI / CT分子成像显示出负/正对比增强。因此，综合结果表明，FePt NPs可能会成为有前景的纳米探针，可用于肿瘤诊断和放化疗的整合。