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Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review.
Mutation Research/Reviews in Mutation Research ( IF 5.3 ) Pub Date : 2015-11-26 , DOI: 10.1016/j.mrrev.2015.07.003
Karl De Ruyck 1 , Marthe De Boevre 1 , Inge Huybrechts 2 , Sarah De Saeger 1
Affiliation  

Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deoxynivalenol, T-2 toxin, HT-2 toxin, patulin, zearalenone, and some ergot alkaloids are outlined. The wide variety of pathogenic mechanisms these compounds employ are shown capable of inducing a complex set of interactions. Of particular note are potential synergisms between mycotoxins with regard to carcinogenic attributable risk, indicating an important field for future study.

中文翻译:

饮食中的霉菌毒素,共同暴露和人类致癌作用:简短评论。

真菌毒素是真菌的有毒次生代谢产物,它对全球农业产生了极大的影响,以致它们在某些普通人类饮食中几乎普遍存在。讨论了体外和体内毒性的研究,从而导致了真菌毒素共暴露的研究以及致癌作用。概述了一些最常见且具有毒理学意义的霉菌毒素,如黄曲霉毒素,曲霉毒素,伏马毒素,脱氧雪腐酚,T-2毒素,HT-2毒素,棒曲霉素,玉米赤霉烯酮和一些麦角生物碱。这些化合物采用多种致病机制,能够诱导复杂的相互作用。特别值得注意的是,霉菌毒素之间在致癌归因风险方面具有潜在的协同作用,为今后的研究提供了重要的领域。
更新日期:2019-11-01
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