System is an antiporter belonging to the hetero(di)meric amino acid transporter family. It is located on astrocytes as well as on blood-brain barrier within the CNS. It plays a pivotal role in free radical neutralization as well as neuronal signalling by regulating the glutathione production which occurs via the exchange of intracellular glutamate with extracellular cystine at 1:1 molar ratio. Understandably, it is a vital component responsible for the maintenance of neuronal homeostasis (e.g. redox state). Hence, it could be postulated that any perturbation in system function may contribute, directly or indirectly, to the pathophysiology of a variety of CNS disorders like Alzheimer’s disease, schizophrenia, drug addiction, depression, multiple sclerosis, hypoglycemic neuronal cell death, glioma, and excitotoxicity, making system a promising target for treating CNS disorders. In recent times, recognizing the potential of this target, variety of inhibitors has been synthesized by modifying commercially available potent inhibitors including sulfasalazine, erastin, and sorafenib. Although, they have demonstrated efficacy, the in-depth data is still lacking to warrant their use for the treatment of aforementioned CNS disorders. In this review, we discuss the in-depth role of system transporter in maintaining normal physiology as well as in the pathophysiology of CNS diseases. Additionally, we have also listed some of the potent inhibitors of system . In conclusion, the critical role of system in multiple CNS disorders and advanced research on its inhibitors have promising future prospects for better management of the CNS ailments.

系统 是属于异（二）聚氨基酸转运蛋白家族的反转运蛋白。它位于中枢神经系统内的星形胶质细胞以及血脑屏障上。它通过调节谷胱甘肽的产生在自由基中和以及神经元信号传导中起关键作用，谷胱甘肽的产生是通过细胞内谷氨酸与细胞外胱氨酸以1：1摩尔比的交换而发生的。可以理解，它是维持神经元稳态（例如氧化还原状态）的重要组成部分。因此，可以假定系统中的任何扰动 功能可能直接或间接地导致多种中枢神经系统疾病的病理生理，例如阿尔茨海默氏病，精神分裂症，药物成瘾，抑郁症，多发性硬化症，低血糖神经元细胞死亡，神经胶质瘤和兴奋性中毒，制造系统 治疗中枢神经系统疾病的有希望的目标。近年来，认识到该靶标的潜力，通过修饰可商购的有效抑制剂包括柳氮磺吡啶，艾司汀和索拉非尼，合成了多种抑制剂。尽管它们已经显示出功效，但是仍然缺乏深入的数据来保证其可用于治疗上述中枢神经系统疾病。在这篇评论中，我们讨论了系统的深入作用转运蛋白在维持正常生理以及中枢神经系统疾病的病理生理中。此外，我们还列出了一些有效的系统抑制剂。总之，系统的关键作用 在多种中枢神经系统疾病中的应用及其抑制剂的进一步研究对于更好地治疗中枢神经系统疾病具有广阔的前景。