Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.

中文翻译：

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肥胖的代谢异质性：脂肪组织的作用

肥胖不是胰岛素抵抗的代名词。为什么有些但不是所有的人会因体重过重而出现胰岛素抵抗，目前尚不清楚，但现在存在许多有充分支持的合理假设。本文回顾了区域脂肪分布、炎症、脂毒性/异位脂肪和脂肪生成受损作为导致体重过重有可能促进胰岛素抵抗的主要理论。